Promising Diabetes Studies

Promising Diabetes Studies

A study published in Nature October 2012

The composition of the gut microbiome seems to be important in regulating body weight. The difference in calorie extraction of ingested food substances may be largely a result of the composition of the gut microbiota. These data support a pivotal role for the gut microbiome and the pathogenesis of obesity, obesity related disorders including diabetes. Intestinal microbiomes have also been studied in relationships to insulin resistance in type 2 diabetes. So dysbiosis or an imbalance in the gut can lead to insulin resistance in type 2 diabetes and then, they say also interestingly the gut microbiome also regulates type 1 diabetes. Data have emerged on the critical role of the gastrointestinal microbiota in the protection or the triggering of type 1 diabetes.

A study published in June 2014

A team of researchers put together a cocktail of different fibers inulin fiber, beta-glucan, anthocyanin rich polyphenos and they found this new therapeutic cocktail was able to change the microbiome of patients with pre-diabetes and type 2 diabetes in just four weeks. The changes corrosponded with improved oral glucose tolerance as well as reduced cholesterol and decreased markers of inflammation. It has become apparent that there are distinct differences between the microbiome in individuals with pre-diabetes, type 2 diabetes and those in the healthy control group.

Both of these studies were mentioned in the diabetes summit as a side note and are from pay sites so I could not attach the actual study. We do have this report from the U.S. Library of Medicine National Institutes of Health on the regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes here.

Also this study, Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes from the U.S. National Library of Medicine Institute of Health here. Consumption of the viscous non-fermentable fiber HPMC decreased diabetic wasting, improved glucose control and reduced insulin resistance and fatty liver in a model of obesity with diabetes. Further reading here.

There is some other incredible research being done from the discovery that the pancreas can regenerate itself which was previously thought impossible. I personally was not surprised because in my years of research I knew that with detoxing and correcting nutrient deficiencies that if you ate as clean and nutritious as possible that in only two years you replace every cell in your body with new healthy cells so why not the pancreas.

Studies on mice are showing that up until puberty the pancreas is capable of regeneration and self healing. Because the pancreatic beta cells are responsible for producing the insulin hormone do not regenerate scientists assumed regeneration of the pancreas was impossible. Recently research done at the University of Geneva has discovered that a few pancreatic alpha cells started to change into beta cells and instead of producing glucagons that raise your blood sugar they started producing insulin. This resulted in the pancreas becoming capable of compensating for the loss of insulin producing beta cells.

Yuval Dor PhD, a professor at the institute for medical research Israel-Canada led a study that shows for the first time that a high rate of glucose metabolism, a process that converts glucose into energy that cells can use, triggers beta cells to regenerate. Coupled with a mechanism that prevents the immune system from attacking beta cells in the first place, the long awaited finding may help pave the way to a full cure for type one diabetes. The study which took five years to complete was published in the April 6 issue of Cell Metabolism. Our work shows as glucose is metabolized, it tells the beta cells to regenerate, it’s not blood glucose that is the signal but the glucose sensing capacity of the beta cell that’s key for regeneration. Full article here.

References and further reading

University of Geneva Research – Swiss National Science Foundation

Pancreatic regeneration

Approaches Toward Endogenous Pancreatic Regeneration – U.S. National Library of Medicine

Regeneration of the Pancreatic Cells – U.S. National Library of Medicine

Interesting article

This one is information only I do not know this company – Microbiome Therapeutics has developed a technology that it says can significantly shift the makeup of the gut microflora in pre-diabetic patients and those with type 2 diabetes. Preliminary data shows the companies flagship product NM504 improved blood glucose response in those patients by shifting the gut microflora from a state of dysbiosis to a normal state. Further reading here.

 

Disclaimer: The information on this site is for educational purposes only and should not be used as a substitute for diagnosis or treatment rendered by a licensed physician. It is essential that you discuss with your doctor any symptoms or medical problems that you may be experiencing.

M. Scherker medical researcher

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